V. Shevchenko, I. Nagaev, N. Myasoedov
May 6, 2009
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Journal
Radiochemistry
Abstract
Methyl p-toluenesulfonates TosOCH23H and TosOCH22H containing, on the average, 0.5 atom of hydrogen isotope per molecule were prepared by catalytic dehalogenation of bromomethyl p-toluenesulfonate TosOCH2Br with tritium and deuterium. Mass-spectrometric analysis showed that the label is fully localized in the methoxy group. The use of this reagent allowed preparation of isotopically labeled biologically active compounds containing the fragments -OCH3, -COOCH3, -SCH3, etc.