A. Bassindale, D. Parker, P. Patel
Jun 19, 2000
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The reaction of chloromethyldimethylsilyl chloride with an amide generates a pentacoordinate N-(amidomethyl)-halosilane that can be desilylated with cesium fluoride to give the N-methyl amide. This provides a selective method for the monoalkylation of amides in the presence of other, more nucleophilic groups.