Jianzhao Liu, Yuanxiang Zhu, Guan-Zheng Luo
Oct 7, 2016
Citations
6
Influential Citations
187
Citations
Quality indicators
Journal
Nature Communications
Abstract
DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1–0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.