T. R. Hovsepyan, S. Dilanyan, N. S. Minasyan
Jul 1, 2018
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0
Influential Citations
4
Citations
Journal
Russian Journal of General Chemistry
Abstract
New 4-substituted 4H-1,2,4-triazole-3-thiol derivatives were synthesized by introducing benzylsulfanylethyl groups in the 5-position of the heterocycle. Alkylation of the thiol group provides additional pharmacophore thioether, carboxamide, carboxyl, and hydroxyethyl fragments. Regardless of the nature of the substituents in the position 5 aminomethylation and cyanoethylation proceed at the N2 atom. The synthesized compounds were studied for anti-tumor activity and the effect on the methylation level of tumor DNA.