B. Strijtveen, B. Feringa, R. Kellogg
Jun 2, 1987
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron
Abstract
Abstract Methylphosphonic dichloride, CH3P(=O)Cl2 , reacts cleanly and quantitatively with thiols to form dialkylthiophosphonates, CH3P(=O) (SR)2. From the ratio of the integrations of the 31P absorptions in the NMR spectra, the enantiomeric excesses of the thiols can be obtained for the cases that R is chiral. The effect of structural change in the phosphorus derivatizing reagent on the separation of peaks in the 31P NMR spectra has been examined, especially the effects of variations in electronegativity and/or steric bulk. The effect of the temperature on the peak separation was also studied.