Jakkrit Srisa, Theeranon Tankam, M. Sukwattanasinitt
Oct 1, 2019
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Influential Citations
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Journal
Chemistry, an Asian journal
Abstract
In this work, we developed a one-pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as a desulfurizing agent under micellar condition in water. Our optimization study revealed that the use of 1% TPGS-750-M as a surfactant with NaOH as an additive base at room temperature can convert a variety of isothiocyanates and amines into corresponding guanidines in excellent yields (69 - 95%). This synthetic process in water can be applied to prepare guanidine at gram-scale quantity. Our aqueous micellar medium also demonstrated high reusability as the reaction can be performed for several cycles without losing its efficiency. The reaction is metal-free, utilize water as solvent and practical (room temperature and open flask).