A. Ma, Shaolin Zhu, D. Ma
May 5, 2008
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0
Influential Citations
63
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The Michael addition of malonates to α,β-unsaturated aldehydes catalyzed by O -TMS protected diphenylprolinols and acetic acid in water occurs at 0 °C to rt. In most cases, the reaction runs to completion in less than 24 h. A wide range of aldehydes including β-aryl, β-alkyl and β-alkenyl acroleins are found to be compatible with these conditions, providing the corresponding adducts in good yields and with good to excellent enantioselectivities.