Nicola Di Iorio, L. Soprani, Simone Crotti
Feb 8, 2017
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Influential Citations
16
Citations
Journal
Synthesis
Abstract
Abstract The desymmetrization of N-(2-tert-butylphenyl)maleimides was realized by means of a Michael reaction of N-(tert-butoxycarbonyl)-3-phenyloxindoles leading to the corresponding axially chiral succinimides in high yields. The use of a squaramide cinchonidine organocatalyst was fundamental to achieve the simultaneous remote control of the stereogenic axis and adjacent quaternary and tertiary stereocenters.