Wu Song
2013
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Using the continuous flow microreactor technology,[2-(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl]-(2-benzyloxy-4,5-methylenedioxyphenyl)methol,the key intermediate of justicidin G,was synthesized from 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane and 3,4-(methylenedioxy)benzaldehyde with a yield of 91.7%.Compared with the conventional reaction,the reaction temperature rised from-78 ℃ to 0 ℃,the reaction time reduced from 4 h to 20 min,and the reaction conditions were mild,safe and effective.