V. Sodha, H. Hirpara, A. Trivedi
Nov 1, 2003
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Journal
ChemInform
Abstract
The reaction of p-(5-formyl-furan-2-yl)benzoic acid 1 with substituted thiazolidinones 2 followed by condensation with ethyl cyanoacetate in the presence of ammonium acetate leading to the formation 4-[5-(6-cyano-5-oxo-3-phenyl-2-phenylimino-2,3,4,5,6,7-hexahydrothiazolo [4,5-b]pyridin-7-yl)furan-2-yl]benzoic acids 4a-m using microwave irradiation and conventional heating has been reported . The reaction rate is enhanced about 120 times using microwaves with improved yield in comparison to conventional method. The synthesised compounds have been characterised on the basis of spectral studies and screened for their antibacterial and antifungal activities.