R. M. Kharate, P. P. Deohate, Shri Sant
Nov 17, 2012
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0
Influential Citations
4
Citations
Journal
Chemical science transactions
Abstract
Synthesis of series of (benzo-(5,6-e)-1,3-diphenyl-2-arylimino-(1,3)-diazepine)-4,7-dione hydrochlorides have been achieved by the interaction of N,N-diphenyl phthalamide with N-aryl isocyanodichlorides by irradiation in a domestic microwave oven for specified time using little chloroform as a solvent along with potassium carbonate. The hydrochlorides were then basified with dilute ammonium hydroxide solution. The parent compound N,N-diphenyl phthalamide was obtained by refluxing the mixture of phthalic anhydride and aniline in toluene. The structures of synthesized compounds were established on the basis of chemical transformation, elemental analysis, IR, 1 H NMR and Mass spectral studies. The synthesized compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.