S. Sondhi, Shubhi Jain, R. Rani
Nov 1, 2007
Citations
0
Influential Citations
5
Citations
Journal
ChemInform
Abstract
Indole-2-carboxylic acid on condensation with benzene sulfonyl hydrazide and p-toluene sulfonyl hydrazide gives condensation products la and 1b. 1H-Tetrazolc-5-acetic acid, hydantoin-5-acetic acid, orotic acid. 5-bromo nicotinic acid and indole 2-carboxylic acid have been condensed with furfuryl amine to give corresponding condensation products 2a-e whereas condensation of succinic acid and adipic acid with furfuryl amine gives products 3a and 3h respectively. 3,5-Pyrazole dicarhoxlic acid, 4,5-imidazole dicarboxylic acid and 3-carboxy-1,4-dimethyl pyrole-2-acetic acid on condensation with furfuryl amine give compounds 4, 5 and 6, All these compounds i.e. 1a,b, 2a-e, 3a,b, 4, 5 and 6 have been characterized by spectroscopic means and have been screened for anti-inflammatory and analgesic activity. Compounds 2a, and 5 exhibit good anti-inflammatory and 2a, 2c and 5 exhibit good analgesic activity.