Deepak Swarnkar, R. Ameta, Ritu Vyas
Dec 1, 2014
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0
Influential Citations
3
Citations
Journal
The Pharma Innovation Journal
Abstract
In the present investigation, microwave assisted synthesis of 3-(4-substituted phenyl)-1-phenylprop-2-en1-ones (Chalcones) (1a-c) were synthesized by base catalyzed aldol condensation of p-substituted benzaldehyde with acetophenone in the presence of piperidine. 3-(4-substituted phenyl)-1-phenylprop-2-en-1-one (Chalcones) (1a-c) was carried out with hydrazine hydrate, phenyl hydrazine, isoniazid, nicotinic hydrazide or thiosemicarbezide in ethanol containing a few drops of glacial acetic acid under microwave irradiation giving 3-(4-substituted phenyl)-5-phenyl2,3-dihydro-1H-pyrazole (2a-c), 3-(4-substituted phenyl)-2-5-diphenyl-2,3-dihydro-1H-pyrazole (3a-c), [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine-4-yl)methanone (4a-c), [5(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine-3-yl)methanone (5a-c), 5-(4substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide (6a-c) derivatives. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1 H NMR spectral data. The synthesized compounds have been screened for their antibacterial and antifungal activities.