A. Dandia, R. Singh, M. Saha
Sep 1, 2002
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Influential Citations
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Journal
Die Pharmazie
Abstract
The microwave induced diastereoselective synthesis of spiro[3H-indole-3,2'-oxiranes]-3'-benzoyl-2 (1H)-one is reported. Epoxidation of 3-aroylmethylene indole-2-one 1 with alkaline H2O2 under microwave irradiation in an open vessel under controlled conditions yields a diastereomeric pair of spiro[3H-indole-3,2'-oxiranes]-3'-benzoyl-2 (1H) ones 2 and 3 in 65-85% yield. The stereoselectivity depends upon the reaction time and power output. The spiro[indole-pyrazoles] 4 have been synthesised by the reaction of 2 with hydrazine hydrate. Under the same condition 3 gave the mixture of products. All synthesised compounds have been screened in vitro for their antifungal activity against Rhizoctonia solani, Fusarium oxysporum and Collectotrichum capsici and antitubercular activity against Mycobacterium tuberculosis.