Wenyong Han, Zunting Zhang, L. Qiu
Aug 22, 2011
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Influential Citations
5
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Journal
Synthetic Communications
Abstract
Abstract Microwave irradiation was used to accelerate the cyclocondensation of isoflavones with 2-aminoimidazole to synthesize 5,6-diphenylimidazo[1,2-a]pyrimidines. A series of 17 new compounds were characterized by Fourier transform infrared, NMR, and elemental analysis. 5-(2-Hydroxyl-4-isopropoxyphenyl)-6-phenylimidazo-[1,2-a]pyrimidine was determined by x-ray diffraction. A variety of substrates can participate in the process with good yields and purities, making this methodology suitable for library synthesis in drug discovery.