Nikalet Everson, Kenya Yniguez, L. Loop
Jan 3, 2019
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Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales.