B. Sailu, K. Ramakrishna, A. Komaraiah
2008
Citations
0
Influential Citations
1
Citations
Journal
Heterocyclic Communications
Abstract
The sulfide intermediate, ('2-[[[3-Methyl-4(2,2,2-trifluoroethoxy)-2pyridinyl] methyl] thio]-lH-benzimidazole) (3), required for the industrial synthesis of the anti-ulcer drug Lansoprazole, has been prepared in excellent yields by microwave irradiation of a dry mixture of 2-chloromethyl-3-methyl-4(2,2,2trifluoroethoxy)pyridine hydrochloride (1) and 2-mercaptobenzimidazole (2) in the presence of Na2C03.