N. Desai, A. Dodiya
Sep 1, 2016
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Influential Citations
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Journal
Arabian Journal of Chemistry
Abstract
Abstract In this paper, we have described the conventional and microwave methods for the synthesis of 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones ( 4a – l ). Through this method, we have observed a decrease in reaction time and a better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which were pollution free and eco-friendly. The structures of the compounds were characterized by IR, NMR and mass spectral data. These compounds ( 4a – l ) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi. Among the compounds tested, compound 4h showed the highest activity.