Firoz A. Jaipuri, M. Jofré, Kimberly Schwarz
May 17, 2004
Citations
1
Influential Citations
20
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A versatile route for the modular synthesis of ( R )-3-hydroxyalkanoic acids, constituents of the naturally biodegradable poly(3-hydroxyalkanoate) polymers, and its application to the synthesis of ( R )-3-hydroxydecanoic acid is described. Key steps include a microwave-assisted catalytic transfer hydrogenation and a facile microwave-assisted hydrolysis of an N -methoxy- N -methyl (Weinreb) amide, which enhances the practicality of this protecting group for carboxylic acids.