Gareth S. Getvoldsen, Anna M K Fredriksson, N. Elander
Feb 1, 2004
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0
Influential Citations
9
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The synthesis of 2-([4-18F]fluorophenyl)benzimidazole, which has potential to be used as a building block for many endogenous and pharmaceutical compounds, is reported. A range of solvents and catalysts as well as conventional and microwave heating have been investigated to optimise the reaction conditions. The cyclocondensation of 1,2-diaminobenzene with radiolabelled [4-18F]fluorobenzoic acid in neat methanesulphonic and polyphosphoric acids under microwave heating led rapidly to the cyclised phenylbenzimidazole. Copyright © 2004 John Wiley & Sons, Ltd.