K. Ostrowska, E. Hejchman, I. Wolska
Aug 16, 2013
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Monatshefte Fur Chemie
Abstract
A series of derivatives of 2 and 3-benzofurancarboxylates were synthesized under microwave-assisted conditions. Their in-vitro antimicrobial properties were assessed. Inhibition by the compounds of the growth of antibiotic-susceptible standards and clinically isolated strains of Gram-positive and Gram-negative bacteria, yeasts, and a human fungal pathogen was moderate to significant. Methyl 5-bromo-7-[2-(N,N-diethylamino)ethoxy]-6-methoxy-2-benzofurancarboxylate hydrochloride was identified as the most active compound (MIC 3–12 × 10−3 μmol/cm3 against Gram-positive bacteria; MIC 9.4 × 10−2 μmol/cm3 against Candida and Aspergillus brasiliensis). The molecular and crystal structures of 2-(N,N-diethylamino)ethyl 6-acetyl-5-hydroxy-2-methyl-3-benzofurancarboxylate were established by single-crystal X-ray diffraction.Graphical Abstract.