P. Soares, Carlos Fernandes, D. Chavarria
Mar 10, 2015
Citations
0
Influential Citations
18
Citations
Journal
Journal of Chemical Education
Abstract
In recent years, the use of boron-containing reagents in palladium-assisted C–C coupling reactions (the Suzuki reaction) has gained prominence due to the vast array of reagents commercially available. Consequently, the generation of carbon–carbon bonds, namely of functionalized biphenyl systems, is at present considered the backbone of organic synthesis. In this context, the design of eco-friendly protocols for the Suzuki reaction employing water as a solvent and the use of microwave-assisted procedures are imperative from an industrial point of view. The series of laboratory experiences described highlight the skillfulness of microwave-assisted synthesis to promote environmentally friendly Suzuki reactions. In the first laboratory class, 1-(4-hydroxy-4′-methoxy-[1,1′-biphenyl]-3-yl)ethanone and 1-(4′-chloro-4-hydroxy-[1,1′-biphenyl]-3-yl)ethanone are synthesized, and the crude products are obtained and purified. Students become acquainted with microwave equipment and several laboratory techniques, such a...