Xianjun Xu, H. Feng, E. V. Van der Eycken
Apr 23, 2021
Citations
0
Influential Citations
8
Citations
Journal
The Journal of organic chemistry
Abstract
1,4-Diamino-2-butynes display both chemical and physiological properties. Here a highly efficient synthesis avenue to generate unsymmetric 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity.