Christelle Lamazzi, Armelle Dreau, C. Bufferne
Aug 5, 2009
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The Letter describes the investigation of an industrial reaction of N -methylphenylpiperazine and chloronicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile ( 4 ), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive ‘ionic alkylating intermediate’ formed in situ under microwave conditions is proposed to explain the results observed.