A. Ribeiro, M. Carvalho, M. Proença
Oct 1, 2009
Citations
0
Influential Citations
9
Citations
Journal
European Journal of Organic Chemistry
Abstract
The reaction of benzylhydroxylamine with 6-cyanopurines leads to the formation of 7-benzyloxy-8-imino-7,8-dihydropyrimido[5,4-d]pyrimidines. The hydrochloride of these compounds, isolated upon addition of aqueous hydrochloric acid, is a convenient precursor of the pyrimido[5,4-d]pyrimidine N-oxides when a suspension of the salt is refluxed in ethanol or acetonitrile. Refluxing a solution of the same salt in ethanol, leads to the Dimroth-rearranged product.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)