A. Dandia, P. Sarawgi, K. Arya
Jan 18, 2007
Citations
0
Influential Citations
10
Citations
Journal
Arkivoc
Abstract
A rapid, efficient, clean and environmentally benign exclusive synthesis of 1,2,4-triazolo(4,3- a)pyrimidines from the reaction of amino triazole, carbonyl compounds and alkene-nitrile derivatives has been developed in an aqueous medium in an excellent yields using microwaves or ultrasonic waves. The results are compared with conventional heating. Structural assignments are based on spectroscopic data (IR, 1 HNMR, 13 CNMR, mass spectra). Further the product structure is confirmed by the single-crystal X-ray molecular structure of 7'-amino-8'H-spiro (cyclohexane- 1,5'-(1,2,4) triazolo (4,3-a) pyrimidine)-6'-carbonitrile (4g).