Bryan Yong-Hao Tan, Yong-Chua Teo
Jun 1, 2015
Citations
0
Influential Citations
6
Citations
Journal
Synlett
Abstract
Abstract A convenient protocol for the C–N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N′-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.