J. Iocono, B. Gildea, L. McLaughlin
1990
Citations
0
Influential Citations
30
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Facile glycosidic bond cleavage of 2-pyrimidinone-2′-deoxynucleosides occurs under mildly acidic conditions (pH 3.0) and ambient temperature. When a 2-pyrimidinone nucleoside residue is present in a DNA fragment, hydrolysis results in an apurinic/apyrimidinic (abasic) site. The incorporation of 2-pyrimidinones into chemically synthesized DNA provides a route for the chemical generation of an abasic site at a preselected position in the sequence.