A. Porcheddu, L. Luca, G. Giacomelli
Dec 1, 2009
Citations
0
Influential Citations
14
Citations
Journal
Synlett
Abstract
A novel and efficient synthetic procedure for converting a diverse set of amines to N,N′ -di-Boc-protected guanidines is described. The methodology comprises the use of cyanuric chloride (TCT) as activating reagent for di-Boc-thiourea. The employ of inexpensive TCT instead of classical HgCl 2 eliminates the environmental hazard of heavy-metal waste without appreciable loss of yield or reactivity. This protocol provides an alternative route for the guanylation of amines from those currently employed.