A. Borghese, L. Antoine, J. V. Hoeck
May 19, 2006
Citations
0
Influential Citations
23
Citations
Journal
Organic Process Research & Development
Abstract
Sulfamides (R1R2N-SO2-NR3R4) are traditionally prepared by using strong electrophilic and hazardous reagents such as N-sulfamoyl chloride, sulfonyl chloride, phosphorus oxychloride, or phosphorus pentachloride. We report here a safer and more convenient synthetic methodology for large-scale preparation of sulfamides using the N-substituted oxazolidin-2-one derivatives 5 as synthetic equivalent of the corrosive and hazardous N-sulfamoyl chloride. The scope of the use of N-sulfamoyloxazolidinones to prepare nonsymmetrical sulfamides is explored.