Sagar N. Ramachandra, C. Srinivasulu, Basavaprabhu Hosamani
Nov 19, 2018
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ChemistrySelect
Abstract
The synthesis of α-ureidopeptidomimetics employing a simple, mild and straight forward route starting from benzyloxy carbonyl (Cbz-) protected amino acid esters in presence of 2-Cl pyridine (2-chloropyridine) and Tf2O (triflic anhydride) in onepot is described. The in situ generated isocyanate intermediates react with amino acid esters to yield the title compounds in good yields (89-96%) and the protocol proved to be racemization free.