Chang Dong-liang
2009
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0
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Journal
Modern Chemical Industry
Abstract
6-Amino-5-bromoquinoxaline is synthesized with 4-nitrobenzene-1,2-diamine as a starting material and followed with cyclization,hydrogenation,bromination by 1,3-dibromo-5,5-dimethylhydantoin in yields of 95.1%,83.3% and 97.6%,respectively.The optimum conditions are as follows:①m(Pd/C)∶m(6-nitroquinoxaline)=1∶20,70℃ of reaction temperature,2 MPa of reaction pressure and 3 hours of reaction time in a catalytic hydrogenation step;②20℃ of reaction temperature,with CH2Cl2 as solvent in a bromination step.The overall yield can reach 77.3%.1,3-Dibromo-5,5-dimethylhydantoin is determined as the best brominating agent.