C. Turnbull, D. Jackson
1984
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Abstract
Mitoxantrone (1,4-dihydroxy-5,8-bis((2-(2-hydroxyethyl)amino)ethyl- amino)-9, 10-anthracenedione hydrochloride NOVANTRONE*) was first synthesized by Murdoch. Based on its antitumor activity in mice and the observation that it did not cause progressive irreversible cardiotoxicity in animals, mitoxantrone was selected for clinical evaluation. An independent effort at the University of Kansas2 also identified mitoxantrone and confirmed the observations of the Lederle investigators in transplantable murine tumors.