A. Shulman
Apr 14, 1956
Citations
0
Influential Citations
3
Citations
Journal
Nature
Abstract
SOME pharmacological properties and clinical uses of 2 : 4-diamino-5-phenyl-thiazole hydrochloride (daptazole or amiphenazole) have been previously considered elsewhere1. It often appears to exert a mild respiratory stimulant effect in both unnarcotized and narcotized patients and animals. It has been used clinically as a buffer to depressed respiration in such conditions as pneumonia, asphyxia neonatorum and in the relief of respiratory depression following anæsthesia. It has further been employed in the treatment of barbiturate intoxication (usually in combination with ββ-methyl ethyl glutarimide (NP13, megimide or bemegride.) and opiate overdosage, and has been administered in combination with large doses of morphine in the relief of severe and prolonged pain. When used in this latter manner, it has appeared to minimize the onset of tolerance or addiction to morphine. It is effective both orally and parenterally, and has a high therapeutic index (greater than 10). Therapeutic doses (5–50 mgm.) are almost completely devoid of side effects, and large doses (more than 200 mgm.) have been safely tolerated by unnarcotized volunteers. In small doses (20–40 mgm.) it often appears to improve the mental outlook of depressed patients.