A. Valla, M. Giraud, J. Dore
Apr 1, 1993
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Influential Citations
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Citations
Journal
Die Pharmazie
Abstract
48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recording, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.