A. Kumari, Ankur Gaur, K. Wasewar
Aug 27, 2018
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Journal
Industrial & Engineering Chemistry Research
Abstract
The present study is aimed to recover the pharmaceutically and biochemically important compound, isonicotinic acid (iNA) from aqueous/fermentation broth in a biocompatible extraction system using an intensified approach, reactive extraction. Tri-n-octylamine (TOA) is used as extractant in nontoxic diluent mixtures of dodecane and n-decanol (modifier) in 1:1 v/v. However, modeling and optimization of reactive extraction using three process parameters, that is, initial iNA concentration in aqueous solution (0.0032–0.0368 kmol·m–3), TOA concentration in organic phase (0.110–1.259 kmol·m–3) and initial pH values of aqueous phase (1.32–4.68) is performed using response surface methodology (RSM), and the rotatable central composite design (rCCD) matrix is used in the experimental design. The RSM model suggests that initial acid concentration is the most influential factor, whereas pH value change shows antagonistic impact on %E. At equilibrium, under constraint condition (lowest TOA concentration selected) that...