D. Khrustalev
May 2, 2009
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Journal
Russian Journal of General Chemistry
Abstract
The high scientific interest attracted by the derivatives of 2-amino-4-phenylthiazole is due to the broad spectrum of biological activity exhibited by these compounds. For instance, in this series substances were found possessing antipyretic, antioxidative, analgesic, and some other types of biological activity [1–3]. The main disadvantage in the synthesis of 2amino-4-phenylthiazole derivatives is the long reaction time [3]. We have studied the possibility of synthesis of 5-amino-containing 2-amino-4-phenyl-thiazole under the conditions of microwave irradiation. The starting substance, 2-amino-5-bromo-4-phenylthiazole, was obtained by bromination of 2-amino-4phenylthiazole I with the molecular bromine in dioxane. Product II was a tar-like brown mass. It was used in further transformations without the additional purification.