V. Sokolov, A. Aksinenko
Nov 1, 2012
Citations
0
Influential Citations
7
Citations
Journal
Russian Chemical Bulletin
Abstract
An approach is proposed to modification of a medical product acetazolamide (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide) by interaction of 2-(5-acetylamino-1,3,4-thiadiazole-2-yl)sulfonyl imine methyl trifluoropyruvate, which is in-situ generated from acetazolamide, with 1,3-binucleophiles: 6-aminouracils, 6-aminothiouracils, and N-substituted ureas, to yield heterocyclic compounds with the CF3 substituent in the nitrogen-containing mono- or bicycle.