Yu Yan-hua
2008
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Journal
Pharmaceutical and Clinical Research
Abstract
Objective:To synthesize methylenediphosphonic acid(MDP) as drug material with improved processes.Methods: Target molecule was synthesized from triethoxy phosphate and dibromoethane by substitution,condensation and hydrolysis.Results: Chemical structure of the product was confirmed by IR,1H NMR and elemental analysis in a total yield of 44.0%.Conclusions: This synthetic technique was simple and practical.