Masayoshi Mochizuki, H. Hibino, Y. Nishiuchi
Oct 16, 2014
Citations
1
Influential Citations
18
Citations
Journal
Organic letters
Abstract
Tritylation using trityl alcohol (Trt-OH) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is a convenient and efficient procedure that can offer S-protection of the Cys located in fully unprotected peptides. The procedure simply requires Trt-OH and HFIP to selectively promote S-tritylation in the presence of peptide nucleophilic functionalities.