Flavia Laffleur, M. Zilio, Duangratana Shuwisitkul
Oct 28, 2016
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Influential Citations
11
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Journal
Therapeutic delivery
Abstract
AIM Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. METHODS Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. RESULTS The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. CONCLUSION Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery.