C. Marques, A. Burke
Feb 1, 2016
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0
Influential Citations
17
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Journal
European Journal of Organic Chemistry
Abstract
Chiral 3-amino-3-aryloxindoles are important biologically active compounds. Using a catalytic modular approach, 31 new 3-amino-3-aryl-2-oxindoles were prepared by a simple Rh-catalysed addition of arylboronic acids to isatin-derived N-Boc-protected ketimines (Boc = tert-butoxycarbonyl). A low catalyst loading of 3 mol-% was used, and the reaction showed a wide scope with high functional-group compatibility, and gave good yields. We report the first catalytic enantioselective reactions with this substrate. Deprotection of the Boc group was easily accomplished in good yields.