Z. You-li
2014
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Quality indicators
Journal
Journal of University of South China
Abstract
In this paper,3,5-difluoropropiophenone is synthetised using 3,5-difluorine benzene nitriles as the raw material reaction with ethyl magnesium bromide. Starting from 3,5-difluoropropiophenone,the four m-difluorine morpholinol hydrochloride are synthetised via several steps including bromination,amination,cyclization and acidification. Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of antidepressant of the synthesized compounds were observed. The target compound is synthetised and its structure is proved by1 H NMR,IR and MS. Results show that compound Ⅵ4have potent antidepressant activities.