Xu Wu, Sheng Ding, Q. Ding
Nov 15, 2002
Citations
3
Influential Citations
192
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.