R. Wakharkar, S. Biswas, H. Borate
Feb 25, 1994
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Journal
Journal of Chromatography A
Abstract
Methyl 7-oxoheptanoate is an important intermediate required for the synthesis of prostaglandins by three-component coupling methodology. It can be efficiently prepared in two steps from cycloheptanone via the formation of 1-methoxy-1-cycloheptene and its ozonolysis. An efficient and reproducible method for the baseline separation of the components in the reaction mixtures in the above steps by gas chromatography is reported.