Lin Tang, Zhen Yang, Jingchao Jiao
Jul 23, 2019
Citations
0
Influential Citations
15
Citations
Journal
The Journal of organic chemistry
Abstract
By altering the amount of Selectfluor, the highly selective mono- and difluorination of 1,3-dicarbonyl compounds has been achieved, affording a variety of 2-fluoro- and 2,2-difluoro-1,3-dicarbonyl compounds in good to excellent yields. The reaction can be readily performed in aqueous media without any catalyst and base, which features a practical and convenient fluorination. Importantly, a gram-scale reaction, transformation of 2-fluoro-1,3-diphenylpropane-1,3-dione to 4-fluoro-1,3,5-triphenyl-1H-pyrazole and chlorination and bromination of 1,3-dicarbonyl compounds are realized to further exhibit its synthetic utility.