X. Han, S. Hong, J. Hwang
Dec 1, 2005
Citations
2
Influential Citations
50
Citations
Quality indicators
Journal
Archives of Pharmacal Research
Abstract
A methylene chloride soluble fraction of the fruits ofCudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O-methylalpinumi-soflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against -B (IC50 0.8 μ?) than -A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.