J. Wieringa, A. V. D. Meerendonk, J. Steenvoorden
Sep 2, 2010
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
A series of 1-[2-[(2-phenoxyphenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines 17–50 (Figure 1) were prepared and tested as inhibitors of biogenic amine re-uptake. In our search for antidepressants, the relationship between their in vitro and in vivo activity as dopamine-reuptake inhibitors is described quantitatively by using Retention Index values determined by reversed-phase liquid chromatography.