L. Wu
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
N1-Methyl-N2-t-butoxycarbonylethylenediamine(1) was prepared from 2-bromoethyl-amine hydrobromide by protection with (Boc)2O and substitution with methylamine in 70.9% total yield. N1-Methyl-N1-t-butoxycarbonylethylenediamine(2) was prepared from N-methylethylenediamine by condensation with phthalic anhydride and Boc group protection of N1 followed by hydrazinolysis in 45.4% overall yield. These methods may be applied for selective mono-Boc protection of other diamines.