Yi‐Feng Wang, Wengang Xu, Bingfeng Sun
Sep 9, 2019
Citations
0
Influential Citations
16
Citations
Journal
The Journal of organic chemistry
Abstract
Commercially available 3,5-bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes. A diverse set of symmetrical and unsymmetrical 9-fluorenones were readily obtained in yields of 32% to 72% along with excellent regioselectivities and broad functional group compatibility as well as high atom economy under mild conditions via dual carbon-hydrogen (C-H) bond activation sequence.